biocatnet CYPED v6.0

CYtochrome P450 Engineering Database version6.0

part of the BioCatNet

This Internet database integrates information on sequence, structure and function of Cytochrome P450 monooxygenases.

The BioCatNet Database System aims to collect and present comprehensive information about biocatalysts: sequence, structure, educts, products, environmental conditions and kinetics. Moreover, it will reveal structure-function relationships to boost development of novel biocatalysts.

To contribute to BioCatNet by submission of functional information, please refer to the information in the BioCatNet Wiki.

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Patrick Buchholz


Gricman Ł., Vogel C. & Pleiss J. (2015). Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining. Proteins 83: 1593-1603.

Gricman Ł., Vogel C. & Pleiss J. (2014). Conservation aalysis of class-specific positions in cytochrome P450 monooxygenases: functional and structural relevance. Proteins 82: 491-504.

Seifert A. & Pleiss J. (2012). Identification of selectivity determinants in CYP monooxygenases by modelling and systematic analysis of sequence and structure. Curr Drug Metab 13: 197-202.

Seifert A., Antonovici M., Hauer B. & Pleiss J. (2011). An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. ChemBioChem 12: 1346-1351.

Sirim D., Widmann M., Wagner F. & Pleiss J. (2010). Prediction and analysis of the modular structure of cytochrome P450 monooxygenases. BMC Struct Biol 10: 34-34.

Sirim D., Wagner F., Lisitsa A. & Pleiss J. (2009). The Cytochrome P450 Engineering Database: integration of biochemical properties. BMC Biochemistry 10: 27.

Seifert A., Vomund S., Grohmann K., Kriening S., Urlacher V.B., Laschat S. & Pleiss J. (2009). Rational design of a minimal and highly enrichedCYP102A1 mutant library with improved regio-, stereo- and chemoselectivity. ChemBioChem 10: 853 -861.

Seifert A. & Pleiss J. (2009). Identification of selectivity-determining residues in cytochrome P450 monooxygenases: a systematic analysis of the substrate recognition site 5. Proteins 74: 1028-1035.

Fischer M., Knoll M., Sirim D., Wagner F., Funke S. & Pleiss J. (2007). The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family. Bioinformatics 23: 2015-2017.